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TRPM2 Functions as a Lysosomal Ca(2+)-Release Channel in β Cells
TRPM2 is a Ca(2+)-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca(2+) influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extra- and intracellularly and caus...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779714/ https://ncbi.nlm.nih.gov/pubmed/19454650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000278 |
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