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Synergistic Regulation Of Endogenous TRPM2 Channels By Adenine Dinucleotides In Primary Human Neutrophils
The Ca(2+)-permeable TRPM2 channel is a dual function protein that is activated by intracellular ADPR through its enzymatic pyrophosphatase domain with Ca(2+) acting as a co-factor. Other TRPM2 regulators include cADPR, NAADP and H(2)O(2), which synergize with ADPR to potentiate TRPM2 activation. Al...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597220/ https://ncbi.nlm.nih.gov/pubmed/18572241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2008.05.001 |
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