TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxi...

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Main Authors: Yamamoto, Shinichiro, Shimizu, Shunichi, Kiyonaka, Shigeki, Takahashi, Nobuaki, Wajima, Teruaki, Hara, Yuji, Negoro, Takaharu, Hiroi, Toshihito, Kiuchi, Yuji, Okada, Takaharu, Kaneko, Shuji, Lange, Ingo, Fleig, Andrea, Penner, Reinhold, Nishi, Miyuki, Takeshima, Hiroshi, Mori, Yasuo
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789807/
https://ncbi.nlm.nih.gov/pubmed/18542050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1758
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