Target identification using drug affinity responsive target stability (DARTS)

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have developed a method, drug affinity responsive target stability (DARTS), which takes advantage of a reduction in the protease susceptibility of the...

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Main Authors: Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M., Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P., Gomez, Fernando, Loo, Joseph A., Wohlschlegel, James A., Vondriska, Thomas M., Pelletier, Jerry, Herschman, Harvey R., Clardy, Jon, Clarke, Catherine F., Huang, Jing
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789755/
https://ncbi.nlm.nih.gov/pubmed/19995983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910040106
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