Target identification using drug affinity responsive target stability (DARTS)

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have developed a method, drug affinity responsive target stability (DARTS), which takes advantage of a reduction in the protease susceptibility of the...

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Detalhes bibliográficos
Main Authors: Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M., Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P., Gomez, Fernando, Loo, Joseph A., Wohlschlegel, James A., Vondriska, Thomas M., Pelletier, Jerry, Herschman, Harvey R., Clardy, Jon, Clarke, Catherine F., Huang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789755/
https://ncbi.nlm.nih.gov/pubmed/19995983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910040106
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