Target identification using drug affinity responsive target stability (DARTS)

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have developed a method, drug affinity responsive target stability (DARTS), which takes advantage of a reduction in the protease susceptibility of the...

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Autori principali: Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M., Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P., Gomez, Fernando, Loo, Joseph A., Wohlschlegel, James A., Vondriska, Thomas M., Pelletier, Jerry, Herschman, Harvey R., Clardy, Jon, Clarke, Catherine F., Huang, Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789755/
https://ncbi.nlm.nih.gov/pubmed/19995983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910040106
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