DNA De-methylation at Specific CpG Sites in the IL1B Promoter in Response to Inflammatory Cytokines in Human Articular Chondrocytes

OBJECTIVE: To determine whether changes in the DNA methylation status in the promoter region of the gene encoding interleukin-1β (IL-1β) account for expression of IL1B mRNA after long-term treatment of human articular chondrocytes with inflammatory cytokines. METHODS: IL-1β or TNFα combined with onc...

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Bibliographic Details
Main Authors: Hashimoto, Ko, Oreffo, Richard O.C., Gibson, Marc B., Goldring, Mary B., Roach, Helmtrud I.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788707/
https://ncbi.nlm.nih.gov/pubmed/19877066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24882
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