Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

The natural tropism of most viral vectors, including adeno-associated viral (AAV) vectors, leads to predominant transduction of neurons and epithelia within the central nervous system (CNS) and retina. Despite the clinical relevance of glia for homeostasis in neural tissue, and as causal contributor...

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Bibliografske podrobnosti
Main Authors: Koerber, James T, Klimczak, Ryan, Jang, Jae-Hyung, Dalkara, Deniz, Flannery, John G, Schaffer, David V
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788045/
https://ncbi.nlm.nih.gov/pubmed/19672246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.184
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