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DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny

Adeno-associated virus (AAV) vectors are extremely effective gene-delivery vehicles for a broad range of applications. However, the therapeutic efficacy of these and other vectors is currently limited by barriers to safe, efficient gene delivery, including pre-existing antiviral immunity, and infect...

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Bibliographic Details
Main Authors: Koerber, James T, Jang, Jae-Hyung, Schaffer, David V
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683895/
https://ncbi.nlm.nih.gov/pubmed/18728640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.167
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