A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection

To engineer gene vectors that target striated muscles after systemic delivery, we constructed a random library of adeno-associated virus (AAV) by shuffling the capsid genes of AAV serotypes 1 to 9, and screened for muscle-targeting capsids by direct in vivo panning after tail vein injection in mice....

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Detalhes bibliográficos
Main Authors: Yang, Lin, Jiang, Jiangang, Drouin, Lauren M., Agbandje-Mckenna, Mavis, Chen, Chunlian, Qiao, Chunping, Pu, Dongqiuye, Hu, Xiaoyun, Wang, Da-Zhi, Li, Juan, Xiao, Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656185/
https://ncbi.nlm.nih.gov/pubmed/19234115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813207106
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