Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

The natural tropism of most viral vectors, including adeno-associated viral (AAV) vectors, leads to predominant transduction of neurons and epithelia within the central nervous system (CNS) and retina. Despite the clinical relevance of glia for homeostasis in neural tissue, and as causal contributor...

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Main Authors: Koerber, James T, Klimczak, Ryan, Jang, Jae-Hyung, Dalkara, Deniz, Flannery, John G, Schaffer, David V
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788045/
https://ncbi.nlm.nih.gov/pubmed/19672246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.184
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