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In vivo–directed evolution of adeno-associated virus in the primate retina
Efficient adeno-associated virus–mediated (AAV-mediated) gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply directed evolution — guided by deep sequencing and followed by direct in vivo secondary selection of high-performing vectors with a GFP-barcoded l...
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| 發表在: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7259523/ https://ncbi.nlm.nih.gov/pubmed/32271719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135112 |
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