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In vivo–directed evolution of adeno-associated virus in the primate retina
Efficient adeno-associated virus–mediated (AAV-mediated) gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply directed evolution — guided by deep sequencing and followed by direct in vivo secondary selection of high-performing vectors with a GFP-barcoded l...
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| Vydáno v: | JCI Insight |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7259523/ https://ncbi.nlm.nih.gov/pubmed/32271719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135112 |
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