Changes in Adeno-Associated Virus-Mediated Gene Delivery in Retinal Degeneration

Gene therapies for retinal degeneration have relied on subretinal delivery of viral vectors carrying therapeutic DNA. The subretinal injection is clearly not ideal as it limits the viral transduction profile to a focal region at the injection site and negatively affects the neural retina by detachin...

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Bibliographic Details
Main Authors: Kolstad, Kathleen D., Dalkara, Deniz, Guerin, Karen, Visel, Meike, Hoffmann, Natalie, Schaffer, David V., Flannery, John G.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143418/
https://ncbi.nlm.nih.gov/pubmed/20021232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.194
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