Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Adeno-associated virus (AAV) vectors have become one of the most widely used gene transfer tools in human gene therapy. Considerable effort is currently being focused on AAV capsid engineering strategies with the aim of developing novel variants with enhanced tropism for specific human cell types, d...

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書誌詳細
出版年:Mol Ther Methods Clin Dev
主要な著者: Cabanes-Creus, Marti, Ginn, Samantha L., Amaya, Anais K., Liao, Sophia H.Y., Westhaus, Adrian, Hallwirth, Claus V., Wilmott, Patrick, Ward, Jason, Dilworth, Kimberley L., Santilli, Giorgia, Rybicki, Arkadiusz, Nakai, Hiroyuki, Thrasher, Adrian J., Filip, Adrian C., Alexander, Ian E., Lisowski, Leszek
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Gene & Cell Therapy 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279885/
https://ncbi.nlm.nih.gov/pubmed/30534580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.10.016
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