Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Adeno-associated virus (AAV) vectors have become one of the most widely used gene transfer tools in human gene therapy. Considerable effort is currently being focused on AAV capsid engineering strategies with the aim of developing novel variants with enhanced tropism for specific human cell types, d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Cabanes-Creus, Marti, Ginn, Samantha L., Amaya, Anais K., Liao, Sophia H.Y., Westhaus, Adrian, Hallwirth, Claus V., Wilmott, Patrick, Ward, Jason, Dilworth, Kimberley L., Santilli, Giorgia, Rybicki, Arkadiusz, Nakai, Hiroyuki, Thrasher, Adrian J., Filip, Adrian C., Alexander, Ian E., Lisowski, Leszek
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279885/
https://ncbi.nlm.nih.gov/pubmed/30534580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.10.016
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge