Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY

Huntingtin (Htt) is a widely expressed protein that causes tissue-specific degeneration when mutated to contain an expanded polyglutamine (poly(Q)) domain. Although Htt is large, 350 kDa, the appearance of amino-terminal fragments of Htt in extracts of postmortem brain tissue from patients with Hunt...

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Detalhes bibliográficos
Main Authors: Aiken, Charity T., Steffan, Joan S., Guerrero, Cortnie M., Khashwji, Hasan, Lukacsovich, Tamas, Simmons, Danielle, Purcell, Judy M., Menhaji, Kimia, Zhu, Ya-Zhen, Green, Kim, LaFerla, Frank, Huang, Lan, Thompson, Leslie Michels, Marsh, J. Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785575/
https://ncbi.nlm.nih.gov/pubmed/19710014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013193
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