JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain incompletely understood. Thus, our...

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Bibliografiset tiedot
Päätekijät: Cazanave, Sophie C., Mott, Justin L., Elmi, Nafisa A., Bronk, Steven F., Werneburg, Nathan W., Akazawa, Yuko, Kahraman, Alisan, Garrison, Sean P., Zambetti, Gerard P., Charlton, Michael R., Gores, Gregory J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Mechanisms of Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785347/
https://ncbi.nlm.nih.gov/pubmed/19638343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022491
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