JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain incompletely understood. Thus, our...

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Библиографические подробности
Главные авторы: Cazanave, Sophie C., Mott, Justin L., Elmi, Nafisa A., Bronk, Steven F., Werneburg, Nathan W., Akazawa, Yuko, Kahraman, Alisan, Garrison, Sean P., Zambetti, Gerard P., Charlton, Michael R., Gores, Gregory J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Mechanisms of Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785347/
https://ncbi.nlm.nih.gov/pubmed/19638343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022491
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