A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA

Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in nonalcoholic fatty liver disease (NAFLD). Lipoapoptosis involves the upregulation of the BH3-only protein PUMA, a potent pro-apoptotic protein. Given that dysregulation of hepatic microRNA expression...

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Autors principals: Cazanave, Sophie C., Mott, Justin L., Elmi, Nafisa A., Bronk, Steven F., Masuoka, Howard C., Charlton, Michael R., Gores, Gregory J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2011
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137017/
https://ncbi.nlm.nih.gov/pubmed/21633093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014654
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