JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain incompletely understood. Thus, our...

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Autors principals: Cazanave, Sophie C., Mott, Justin L., Elmi, Nafisa A., Bronk, Steven F., Werneburg, Nathan W., Akazawa, Yuko, Kahraman, Alisan, Garrison, Sean P., Zambetti, Gerard P., Charlton, Michael R., Gores, Gregory J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785347/
https://ncbi.nlm.nih.gov/pubmed/19638343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022491
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