Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis

BACKGROUNDS AND AIMS: Saturated free fatty acids induce hepatocyte lipoapoptosis, a key pathologic feature of nonalcoholic steatohepatitis. The saturated free fatty acid palmitate induces hepatocyte lipoapoptosis via an endoplasmic reticulum stress pathway resulting in c-Jun-N-terminal (JNK) activat...

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Main Authors: Ibrahim, Samar H., Akazawa, Yuko, Cazanave, Sophie C., Bronk, Steven F., Elmi, Nafisa A., Werneburg, Nathan W., Billadeau, Daniel D., Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060963/
https://ncbi.nlm.nih.gov/pubmed/21147505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.09.039
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