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Glycogen Synthase Kinase-3 (GSK-3) Inhibition Attenuates Hepatocyte Lipoapoptosis
BACKGROUNDS AND AIMS: Saturated free fatty acids induce hepatocyte lipoapoptosis, a key pathologic feature of nonalcoholic steatohepatitis. The saturated free fatty acid palmitate induces hepatocyte lipoapoptosis via an endoplasmic reticulum stress pathway resulting in c-Jun-N-terminal (JNK) activat...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060963/ https://ncbi.nlm.nih.gov/pubmed/21147505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.09.039 |
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