Mcl-1 Degradation during Hepatocyte Lipoapoptosis

The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonstrate that Mcl-1, an anti-apoptotic member of the Bcl-2 family, was rapidly degraded in hepatocytes in response to palmitate and stearate by a proteasome-dependent pathway. Overexpression of a ubiquiti...

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Bibliographic Details
Main Authors: Masuoka, Howard C., Mott, Justin, Bronk, Steven F., Werneburg, Nathan W., Akazawa, Yuko, Kaufmann, Scott H., Gores, Gregory J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781558/
https://ncbi.nlm.nih.gov/pubmed/19734538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039545
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