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Mcl-1 Degradation during Hepatocyte Lipoapoptosis
The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonstrate that Mcl-1, an anti-apoptotic member of the Bcl-2 family, was rapidly degraded in hepatocytes in response to palmitate and stearate by a proteasome-dependent pathway. Overexpression of a ubiquiti...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781558/ https://ncbi.nlm.nih.gov/pubmed/19734538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039545 |
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