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Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response
The N-terminal transcription activation domain of p53 is intrinsically unstructured. We show in vitro and in vivo that this domain initiates p53 degradation by the 20 S proteasome in a ubiquitin-independent fashion. The decay of metabolically labeled p53 follows biphasic kinetics with an immediate f...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785311/ https://ncbi.nlm.nih.gov/pubmed/19617345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.040493 |
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