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Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake

Brain amyloid-β (Aβ) peptide accumulation and aggregation are critical events in the pathogenesis of Alzheimer disease. Increasing evidence has demonstrated that LRP1 is involved in Alzheimer disease pathogenesis. The physiological ligands of LRP1, including apoE, play significant roles in the cellu...

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Autori principali: Kanekiyo, Takahisa, Bu, Guojun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785178/
https://ncbi.nlm.nih.gov/pubmed/19826010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015032
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