The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in an in Vitro Model of the Blood-Brain Barrier Cells

The metabolism of amyloid β peptide (Aβ) in the brain is crucial to the pathogenesis of Alzheimer disease. A body of evidence suggests that Aβ is actively transported from brain parenchyma to blood across the blood-brain barrier (BBB), although the precise mechanism remains unclear. To unravel the c...

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Main Authors: Yamada, Kaoru, Hashimoto, Tadafumi, Yabuki, Chiori, Nagae, Yusuke, Tachikawa, Masanori, Strickland, Dudley K., Liu, Qiang, Bu, Guojun, Basak, Jacob M., Holtzman, David M., Ohtsuki, Sumio, Terasaki, Tetsuya, Iwatsubo, Takeshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Membrane Transport, Structure, Function, and Biogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596389/
https://ncbi.nlm.nih.gov/pubmed/18940800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801487200
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