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Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
One of the neuropathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque, primarily composed of aggregated amyloid-beta (Aβ) peptide. In vitro, Aβ(1–42), the major alloform of Aβ found in plaques, self-assembles into fibrils at micromolar concentrations and acidic pH. Such condi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787156/ https://ncbi.nlm.nih.gov/pubmed/19910533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911281106 |
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