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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

We have used fluorescence correlation spectroscopy measurements to quantify the hydrodynamic sizes of monomeric polyglutamine as a function of chain length (N) by measuring the scaling of translational diffusion times (τ(D)) for the peptide series (Gly)-(Gln)(N)-Cys-Lys(2) in aqueous solution. We fi...

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Detalhes bibliográficos
Main Authors: Crick, Scott L., Jayaraman, Murali, Frieden, Carl, Wetzel, Ronald, Pappu, Rohit V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1629004/
https://ncbi.nlm.nih.gov/pubmed/17075061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608175103
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