Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

One of the neuropathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque, primarily composed of aggregated amyloid-beta (Aβ) peptide. In vitro, Aβ(1–42), the major alloform of Aβ found in plaques, self-assembles into fibrils at micromolar concentrations and acidic pH. Such condi...

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Detaylı Bibliyografya
Asıl Yazarlar: Hu, Xiaoyan, Crick, Scott L., Bu, Guojun, Frieden, Carl, Pappu, Rohit V., Lee, Jin-Moo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787156/
https://ncbi.nlm.nih.gov/pubmed/19910533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911281106
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