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Effect of Chirality of Small Molecule Organofluorine Inhibitors of Amyloid Self-Assembly on Inhibitor Potency

The effect of enantiomeric trifluromethyl-indolyl-acetic acid ethyl esters on the fibrillogenesis of Alzheimer's amyloid β (Aβ) peptide is described. These compounds have been previously identified as effective inhibitors of the Aβ self-assembly in their racemic form. Thioflavin-T Fluorescence...

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Detalhes bibliográficos
Main Authors: Sood, Abha, Abid, Mohammed, Hailemichael, Samson, Foster, Michelle, Török, Béla, Török, Marianna
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785120/
https://ncbi.nlm.nih.gov/pubmed/19880318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.066
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