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Effect of Chirality of Small Molecule Organofluorine Inhibitors of Amyloid Self-Assembly on Inhibitor Potency
The effect of enantiomeric trifluromethyl-indolyl-acetic acid ethyl esters on the fibrillogenesis of Alzheimer's amyloid β (Aβ) peptide is described. These compounds have been previously identified as effective inhibitors of the Aβ self-assembly in their racemic form. Thioflavin-T Fluorescence...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785120/ https://ncbi.nlm.nih.gov/pubmed/19880318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.066 |
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