Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has rem...

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Detalhes bibliográficos
Main Authors: Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., Schinzel, Anna C., Sandy, Peter, Meylan, Etienne, Scholl, Claudia, Fröhling, Stefan, Chan, Edmond M., Sos, Martin L., Michel, Kathrin, Mermel, Craig, Silver, Serena J., Weir, Barbara A., Reiling, Jan H., Sheng, Qing, Gupta, Piyush B., Wadlow, Raymond C., Le, Hanh, Hoersch, Sebastian, Wittner, Ben S., Ramaswamy, Sridhar, Livingston, David M., Sabatini, David M., Meyerson, Matthew, Thomas, Roman K., Lander, Eric S., Mesirov, Jill P., Root, David E., Gilliland, D. Gary, Jacks, Tyler, Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783335/
https://ncbi.nlm.nih.gov/pubmed/19847166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08460
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