AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs commonly in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase. However, here we show through phospho-protein pro...

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Päätekijät: Vasudevan, Krishna M., Barbie, David A., Davies, Michael A., Rabinovsky, Rosalia, McNear, Chontelle J., Kim, Jessica J., Hennessy, Bryan T., Tseng, Hsiuyi, Pochanard, Panisa, Kim, So Young, Dunn, Ian F., Schinzel, Anna C., Sandy, Peter, Hoersch, Sebastian, Sheng, Qing, Gupta, Piyush B., Boehm, Jesse S., Reiling, Jan H., Silver, Serena, Lu, Yiling, Stemke-Hale, Katherine, Dutta, Bhaskar, Joy, Corwin, Sahin, Aysegul A., Gonzalez-Angulo, Ana Maria, Lluch, Ana, Rameh, Lucia E., Jacks, Tyler, Root, David E., Lander, Eric S., Mills, Gordon B., Hahn, William C., Sellers, William R., Garraway, Levi A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752826/
https://ncbi.nlm.nih.gov/pubmed/19573809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.04.012
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