High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in >80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K pathway members being more common than predicted by chance. PIK3R1 (p85α) mutations occur at a higher rate in endometrial canc...

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Hoofdauteurs: Cheung, Lydia W.T., Hennessy, Bryan T., Li, Jie, Yu, Shuangxing, Myers, Andrea P., Djordjevic, Bojana, Lu, Yiling, Stemke-Hale, Katherine, Zhang, Fan, Ju, Zhenlin, Cantley, Lewis C., Scherer, Steven E., Liang, Han, Lu, Karen H., Broaddus, Russell R., Mills, Gordon B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187555/
https://ncbi.nlm.nih.gov/pubmed/21984976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0039
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