Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway dictating therapeutic response to MAPK pathway inhibitors

PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348*) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mutations in other regions of PIK3R1, confers an unexpected se...

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Detalhes bibliográficos
Main Authors: Cheung, Lydia W.T., Yu, Shuangxing, Zhang, Dong, Li, Jie, Ng, Patrick K.S., Panupinthu, Nattapon, Mitra, Shreya, Ju, Zhenlin, Yu, Qinghua, Liang, Han, Hawke, David H., Lu, Yiling, Broaddus, Russell R., Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198486/
https://ncbi.nlm.nih.gov/pubmed/25284480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.08.017
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