Autophagy inhibition dysregulates TBK1 signaling and promotes pancreatic inflammation

Autophagy promotes tumor progression downstream of oncogenic KRAS, yet also restrains inflammation and dysplasia through mechanisms that remain incompletely characterized. Understanding the basis of this paradox has important implications for the optimal targeting of autophagy in cancer. Using a mou...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Yang, Shenghong, Imamura, Yu, Jenkins, Russell W., Cañadas, Israel, Kitajima, Shunsuke, Aref, Amir, Brannon, Arthur, Oki, Eiji, Castoreno, Adam, Zhu, Zehua, Thai, Tran, Reibel, Jacob, Qian, Zhirong, Ogino, Shuji, Wong, Kwok K., Baba, Hideo, Kimmelman, Alec C., Di Magliano, Marina Pasca, Barbie, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891226/
https://ncbi.nlm.nih.gov/pubmed/27068336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0235
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