Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3

Treatment of human head and neck squamous cell carcinoma (HNSCC) cell lines with guggulsterone, a widely available, well-tolerated nutraceutical, demonstrated dose-dependent decreases in cell viability with EC(50)s ranging from 5 to 8 μM. Guggulsterone induced apoptosis and cell cycle arrest, inhibi...

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Hlavní autoři: Leeman-Neill, Rebecca J., Wheeler, Sarah E., Singh, Shivendra V., Thomas, Sufi M., Seethala, Raja R., Neill, Daniel B., Panahandeh, Mary C., Hahm, Eun-Ryeong, Joyce, Sonali C., Sen, Malabika, Cai, Quan, Freilino, Maria L., Li, Changyou, Johnson, Daniel E., Grandis, Jennifer R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783003/
https://ncbi.nlm.nih.gov/pubmed/19762335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp211
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