Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether...

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Main Authors: Gandhi, Prafull S., Page, Michael J., Chen, Zhiwei, Bush-Pelc, Leslie, Di Cera, Enrico
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782003/
https://ncbi.nlm.nih.gov/pubmed/19586901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025403
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