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Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A
The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782003/ https://ncbi.nlm.nih.gov/pubmed/19586901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025403 |
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