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Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether...

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Autores principales: Gandhi, Prafull S., Page, Michael J., Chen, Zhiwei, Bush-Pelc, Leslie, Di Cera, Enrico
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782003/
https://ncbi.nlm.nih.gov/pubmed/19586901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025403
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