Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gandhi, Prafull S., Page, Michael J., Chen, Zhiwei, Bush-Pelc, Leslie, Di Cera, Enrico
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782003/
https://ncbi.nlm.nih.gov/pubmed/19586901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025403
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