p16(INK4A) Sensitizes Human Leukemia Cells to FAS- and Glucocorticoid-induced Apoptosis via Induction of BBC3/Puma and Repression of MCL1 and BCL2

Loss of CDKN2A/p16(INK4A) in hematopoietic stem cells is associated with enhanced self-renewal capacity and might facilitate progression of damaged stem cells into pre-cancerous cells that give rise to leukemia. This is also reflected by the frequent loss of the INK4A locus in acute lymphoblastic T-...

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Detalhes bibliográficos
Main Authors: Obexer, Petra, Hagenbuchner, Judith, Rupp, Martina, Salvador, Christina, Holzner, Markus, Deutsch, Martin, Porto, Verena, Kofler, Reinhard, Unterkircher, Thomas, Ausserlechner, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781493/
https://ncbi.nlm.nih.gov/pubmed/19737931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051441
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