A Genome-Wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide siRNA screen in a human cellular clock model. Knockdown of nearly a thousand ge...

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Hlavní autoři: Zhang, Eric E., Liu, Andrew C., Hirota, Tsuyoshi, Miraglia, Loren J., Welch, Genevieve, Pongsawakul, Pagkapol Y., Liu, Xianzhong, Atwood, Ann, Huss, Jon W., Janes, Jeff, Su, Andrew I., Hogenesch, John B., Kay, Steve A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777987/
https://ncbi.nlm.nih.gov/pubmed/19765810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.08.031
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