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Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

Either expression level or transcriptional activity of various nuclear receptors (NRs) have been demonstrated to be under circadian control. With a few exceptions, little is known about the roles of NRs as direct regulators of the circadian circuitry. Here we show that the nuclear receptor HNF4A str...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Qu, Meng, Duffy, Tomas, Hirota, Tsuyoshi, Kay, Steve A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310821/
https://ncbi.nlm.nih.gov/pubmed/30530698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816411115
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