Feedback repression is required for mammalian circadian clock function

Direct evidence for the requirement of transcriptional feedback repression in circadian clock function has been elusive. Here, we developed a molecular genetic screen in mammalian cells to identify mutants of the circadian transcriptional activators CLOCK and BMAL1, which were uncoupled from CRYPTOC...

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Detalhes bibliográficos
Main Authors: Sato, Trey K, Yamada, Rikuhiro G, Ukai, Hideki, Baggs, Julie E, Miraglia, Loren J, Kobayashi, Tetsuya J, Welsh, David K, Kay, Steve A, Ueda, Hiroki R, Hogenesch, John B
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994933/
https://ncbi.nlm.nih.gov/pubmed/16474406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1745
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