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Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

Regulated degradation of proteins by the proteasome is often critical to their function in dynamic cellular pathways. The molecular clock underlying mammalian circadian rhythms relies on the rhythmic expression and degradation of its core components. However, because the tools available for identify...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: DeBruyne, Jason P., Baggs, Julie E., Sato, Trey K., Hogenesch, John B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603519/
https://ncbi.nlm.nih.gov/pubmed/26392558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501204112
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