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Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

Regulated degradation of proteins by the proteasome is often critical to their function in dynamic cellular pathways. The molecular clock underlying mammalian circadian rhythms relies on the rhythmic expression and degradation of its core components. However, because the tools available for identify...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: DeBruyne, Jason P., Baggs, Julie E., Sato, Trey K., Hogenesch, John B.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603519/
https://ncbi.nlm.nih.gov/pubmed/26392558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501204112
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