Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen

Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase (TcDHFR-TS) was crystallized in complexes with the dihydrotriazine-based or quinazoline-based antifolates C-448, cycloguanil (CYC) and Q-8 in order to gain insight into the interactions of this DHFR enzyme with classical and novel inhibi...

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Main Authors: Chitnumsub, Penchit, Yuvaniyama, Jirundon, Chahomchuen, Thippayarat, Vilaivan, Tirayut, Yuthavong, Yongyuth
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2009
Assuntos:
Crystallization Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777052/
https://ncbi.nlm.nih.gov/pubmed/19923744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109041979
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