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Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E(2)

Cyclooxygenase isoform-2 (COX-2) and microsomal prostaglandin E(2) synthase-1 (mPGES-1) are inducible enzymes that become up-regulated in inflammation and some cancers. It has been demonstrated that their coupling reaction of converting arachidonic acid (AA) into prostaglandin (PG) E(2) (PGE(2)) is...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ruan, Ke-He, Cervantes, Vanessa, So, Shui-Ping
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777022/
https://ncbi.nlm.nih.gov/pubmed/19850676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp058
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