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Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E(2)
Cyclooxygenase isoform-2 (COX-2) and microsomal prostaglandin E(2) synthase-1 (mPGES-1) are inducible enzymes that become up-regulated in inflammation and some cancers. It has been demonstrated that their coupling reaction of converting arachidonic acid (AA) into prostaglandin (PG) E(2) (PGE(2)) is...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777022/ https://ncbi.nlm.nih.gov/pubmed/19850676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp058 |
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