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Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential
Recently, we reported that a novel hybrid enzyme (TriCat Enzyme), engineered by linking human cyclo-ooxygenase-2 (COX-2) with prostacyclin (PGI(2)) synthase (PGIS) together through a transmembrane domain, was able to directly integrate the triple catalytic (TripCat) functions of COX-2 and PGIS and e...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717720/ https://ncbi.nlm.nih.gov/pubmed/18835243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.09.010 |
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