Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential

Lignende værker

• An active triple-catalytic hybrid enzyme engineered by linking COX-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector
  af: Ruan, Ke-He, et al.
  Udgivet: (2008)
• Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E(2)
  af: Ruan, Ke-He, et al.
  Udgivet: (2009)
• A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor
  af: Ni, Feng, et al.
  Udgivet: (2007)
• Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease
  af: Ruan, Cheng-Huai, et al.
  Udgivet: (2010)
• Substrate access channel topology in membrane-bound prostacyclin synthase.
  af: Deng, Hui, et al.
  Udgivet: (2002)