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Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

AIM: Our aim is to understand the molecular mechanisms of the selective nonsteroidal anti-inflammatory drugs (NSAID), cyclooxygenase-2 (COX-2) inhibitors', higher “priority” to reduce synthesis of the vascular protector, prostacyclin (PGI2), compared to that of nonselective NSAIDs. MAIN METHODS...

詳細記述

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書誌詳細
主要な著者: Ruan, Cheng-Huai, So, Shui-Ping, Ruan, Ke-He
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046773/
https://ncbi.nlm.nih.gov/pubmed/21035466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2010.10.017
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