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An active triple-catalytic hybrid enzyme engineered by linking COX-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector

It remains a challenge to create the stable and long-term expression (in human cell lines) of a previously engineered hybrid enzyme (Trip-cat enzyme-2, [Ruan, KH., et al. (2006) Biochemistry 45, 14003 – 14011]), which links cyclooxygenase-2 (COX-2) to prostacyclin (PGI(2)) synthase (PGIS) for the di...

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מידע ביבליוגרפי
Main Authors: Ruan, Ke-He, So, Shui-Ping, Cervantes, Vanessa, Wu, Hanjing, Wijaya, Cori, Jentzen, Rebecca R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038792/
https://ncbi.nlm.nih.gov/pubmed/19021758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06703.x
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