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An active triple-catalytic hybrid enzyme engineered by linking COX-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector
It remains a challenge to create the stable and long-term expression (in human cell lines) of a previously engineered hybrid enzyme (Trip-cat enzyme-2, [Ruan, KH., et al. (2006) Biochemistry 45, 14003 – 14011]), which links cyclooxygenase-2 (COX-2) to prostacyclin (PGI(2)) synthase (PGIS) for the di...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038792/ https://ncbi.nlm.nih.gov/pubmed/19021758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06703.x |
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