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Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy

Activation of renal interstitial fibroblasts is critically involved in the development of tubulointerstitial fibrosis in chronic kidney diseases. In this study, we investigated the effect of trichostatin A (TSA), a specific histone deacetylase (HDAC) inhibitor, on the activation of renal interstitia...

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Detalhes bibliográficos
Main Authors: Pang, Maoyin, Kothapally, Jagan, Mao, Haiping, Tolbert, Evelyn, Ponnusamy, Murugavel, Chin, Y. Eugene, Zhuang, Shougang
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775583/
https://ncbi.nlm.nih.gov/pubmed/19640900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00282.2009
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