Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy

Activation of renal interstitial fibroblasts is critically involved in the development of tubulointerstitial fibrosis in chronic kidney diseases. In this study, we investigated the effect of trichostatin A (TSA), a specific histone deacetylase (HDAC) inhibitor, on the activation of renal interstitia...

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Main Authors: Pang, Maoyin, Kothapally, Jagan, Mao, Haiping, Tolbert, Evelyn, Ponnusamy, Murugavel, Chin, Y. Eugene, Zhuang, Shougang
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775583/
https://ncbi.nlm.nih.gov/pubmed/19640900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00282.2009
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