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Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy

Activation of renal interstitial fibroblasts is critically involved in the development of tubulointerstitial fibrosis in chronic kidney diseases. In this study, we investigated the effect of trichostatin A (TSA), a specific histone deacetylase (HDAC) inhibitor, on the activation of renal interstitia...

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Bibliografiske detaljer
Main Authors: Pang, Maoyin, Kothapally, Jagan, Mao, Haiping, Tolbert, Evelyn, Ponnusamy, Murugavel, Chin, Y. Eugene, Zhuang, Shougang
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775583/
https://ncbi.nlm.nih.gov/pubmed/19640900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00282.2009
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