Blocking Sirtuin 1 and 2 Inhibits Renal Interstitial Fibroblast Activation and Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy

Our recent studies revealed that blocking class I/II histone deacetylases (HDACs) inhibits renal interstitial fibroblast activation and proliferation and alleviates development of renal fibrosis. However, the effect of class III HDAC, particularly sirtuin 1 and 2 (SIRT1 and SIRT2), inhibition on ren...

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Hlavní autoři: Ponnusamy, Murugavel, Zhou, Xiaoxu, Yan, Yanli, Tang, Jinhua, Tolbert, Evelyn, Zhao, Ting C., Gong, Rujun, Zhuang, Shougang
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
Témata:
Gastrointestinal, Hepatic, Pulmonary, and Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109489/
https://ncbi.nlm.nih.gov/pubmed/24833701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.212076
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